4. Developmental toxicity : focusing in dioxins
نویسندگان
چکیده
منابع مشابه
Dioxins and human toxicity.
The term dioxins usually refers to polychlorinated dibenzo-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). As 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) has the highest toxic potential, the toxic potentials of other PCDDs and PCDFs are defined in comparison with it. Human exposure to dioxins can be environmental (background), occupational, or accidental pollution. In the human body,...
متن کاملDevelopmental effects of dioxins.
The potent developmental toxicity of dioxin in multiple species has been known for a number of years. However, recent studies have indicated that dioxin also induces functional developmental defects, many of which are delayed. Subtle structural deficits, not detectable at birth, have also been described in multiple species and in both sexes. Certain defects have been reported not only in animal...
متن کاملTranscriptomics in developmental toxicity testing
Reproductive toxicity testing is one of the most complex, expensive and labor intensive fields of toxicology (Leist et al. drastically demonstrate the fundamental importance of reliable developmental toxicity tests for human safety (van Recently, human embryonic stem cell based in vitro test systems have been established that recapitulate critical periods of human early development (Krug et al....
متن کاملMale-mediated developmental toxicity
In recent years, the public has become more aware that exposure of males to certain agents can adversely affect their offspring and cause infertility and cancer. The hazards associated with exposure to ionising radiation have been recognised for nearly a century, but interest was aroused when a cluster of leukaemia cases was identified in young children living in Seascale, close to the nuclear ...
متن کاملThe problem of maternal toxicity in developmental toxicity studies.
Guidelines for developmental toxicity studies require that the highest dose(s) should induce some signs of maternal toxicity. However, the interpretation of the results is often difficult when developmentally toxic effects are recorded only at maternotoxic doses, as it is impossible to ascertain whether the developmental effects are maternally mediated or not. In order to avoid this source of m...
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ژورنال
عنوان ژورنال: Sangyo Eiseigaku Zasshi
سال: 1999
ISSN: 1341-0725,1349-533X
DOI: 10.1539/sangyoeisei.kj00001990883